Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease Running title: Jensen et al.; Protein interaction-based GWAS of CHD
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Protein interaction-based genome-wide analysis of incident coronary heart disease.
BACKGROUND Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD). METHODS AND RESULTS Genome-wide associat...
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African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2,905 African Americ...
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Since the beginning of the era of genome-wide association studies (GWAS), . 1200 human GWAS have now examined . 200 diseases and traits, and found almost 4000 single nucleotide polymorphism (SNP) associations. This number is quite impressive, but up to now it is largely unknown how we can incorporate these findings into the clinical setting. One of the challenges for successful GWAS in the futu...
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BACKGROUND Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future ...
متن کاملGenome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
BACKGROUND Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. METHODS We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5...
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